鐘文彬，博士，教授，“南山學(xué)者”優(yōu)秀人才，博士生導(dǎo)師，博士后合作導(dǎo)師

學(xué)術(shù)任職

1、中國(guó)生物化學(xué)與分子生物學(xué)會(huì)脂質(zhì)與脂蛋白專(zhuān)業(yè)委員會(huì) 委員

2、廣東省抗癌協(xié)會(huì)腫瘤代謝專(zhuān)業(yè)委員會(huì) 委員

聯(lián)系方式：Email: [email protected]；Tel: 15913146856。

研究領(lǐng)域

1、細(xì)胞代謝重構(gòu)與血液細(xì)胞惡性轉(zhuǎn)化機(jī)理

2、白血病細(xì)胞生存、免疫逃逸和耐藥的分子機(jī)理

3、新型抗白血病靶向藥物研發(fā)

以第一作者或通訊作者在國(guó)際學(xué)術(shù)期刊Science Translational Medicine，Blood，Nature Communications，Circulation Research，Cell Reports，J Biol Chem等發(fā)表研究論文10多篇。

科研項(xiàng)目

1、 國(guó)家自然科學(xué)基金面上項(xiàng)目，2024-2027，49萬(wàn)

2、 國(guó)家自然科學(xué)基金青年項(xiàng)目，2020-2022，24萬(wàn)

3、 廣州醫(yī)科大學(xué)“南山學(xué)者”啟動(dòng)基金，2023-2027，500萬(wàn)

4、 暨南大學(xué)高層次人才科研配套經(jīng)費(fèi)，2018-2021，100萬(wàn)

5、 暨南大學(xué)中央高?；究蒲袠I(yè)務(wù)費(fèi)，2019-2021，15萬(wàn)

代表性論著

1、Chen, H., Lu, C., Tan, Y., Marion Weber-Boyvat, Zheng, J., Xu, M., Xiao, J., Liu, S., Tang, Z., Lai, C., Li, M., Vesa M Olkkonen, Yan, D., Zhong, W. (2023) Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P2 hydrolysis in the plasma membrane. J Biol Chem. 299(6):104812. (IF: 5.4, 2區(qū)TOP)

2、Zhong，W., Cao X., Pan G., Niu Q., Feng X., Xu M., Li M., Huang Y., Yi Q., Yan D. (2022) Oxysterol-binding protein-related protein 4L (ORP4L) is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1 (HTLV-1). Blood. 139 (7): 1052–1065. (IF: 25.4, 1區(qū))

3、Zhu B., Zhong W., Pan G., Cao X., Xu M., Zheng J., Chen H., Feng X., Luo C., Lu C., Lin W., Lai C., Du X., Yi Q., Yan D. (2022) Loss of miR-31-5p drives hematopoietic stem cell deterioration and restoration eliminates leukemia stem cells. Sci Transl Med 14(629):eabh2548. (IF: 19.3，1區(qū)), 新華社報(bào)道 （http://www.news.cn/english/20220127/bfa3590bda504df9ad495cd1bcff974b/c.html）.

4、Zhong W, Lin W, Yang Y, Chen D, Cao X, Xu M, Pan G, Chen H, Zheng J, Feng X, Yang LH, Lai C, Olkkonen VM, Xu J, Cui S, Yan D. (2022) An acquired PI(4)P transport initiates T-cell deterioration. Nat Commun. 29;13(1):4390. (IF：17.6，1區(qū))。

5、Xu, M., Zhu, B., Cao, X., Li, S., Li, D., Zhou, H., Olkkonen, V. M., Zhong, W., Xu, J., and Yan, D. (2020) OSBP-Related Protein 5L Maintains Intracellular IP3/Ca(2+) Signaling and Proliferation in T Cells by Facilitating PIP2 Hydrolysis. J Immunol 204, 1134-1145. (IF: 5.4，2區(qū)TOP)

6、Cao, X., Chen, J., Li, D., Xie, P., Xu, M., Lin, W., Li, S., Pan, G., Tang, Y., Xu, J., Olkkonen, V. M., Yan, D., and Zhong, W. (2019) ORP4L couples IP3 to ITPR1 in control of endoplasmic reticulum calcium release. FASEB J 33, 13852-13865. (IF: 5.8，2區(qū)TOP)

7、Pan, G., Cao, X., Liu, B., Li, C., Li, D., Zheng, J., Lai, C., Olkkonen, V. M., Zhong, W., and Yan, D. (2018) OSBP-related protein 4L promotes phospholipase Cbeta3 translocation from the nucleus to the plasma membrane in Jurkat T-cells. J Biol Chem 293, 17430-17441. (IF: 5.4, 2區(qū)TOP)

8、 Zhu, B., Cao, X., Zhang, W., Pan, G., Yi, Q., Zhong, W., and Yan, D. (2019) MicroRNA-31-5p enhances the Warburg effect via targeting FIH. FASEB J 33, 545-556. (IF: 5.8，2區(qū)TOP，ESI高被引論文)

9、Zhong, W., Xu, M., Li, C., Zhu, B., Cao, X., Li, D., Chen, H., Hu, C., Li, R., Luo, C., Pan, G., Zhang, W., Lai, C., Wang, T., Du, X., Chen, H., Xu, G., Olkkonen, V. M., Lei, P., Xu, J., and Yan, D. (2019) ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCbeta3 Catalysis: Targeting It Eradicates Leukemia Stem Cells. Cell Rep 26, 2166-2177 e2169. (IF: 9.9，1區(qū))，中國(guó)科學(xué)報(bào)報(bào)道（https://news.sciencenet.cn/sbhtmlnews/2019/2/343620.shtm）.

10、Zhong, W., Pan, G., Wang, L., Li, S., Ou, J., Xu, M., Li, J., Zhu, B., Cao, X., Ma, H., Li, C., Xu, J., Olkkonen, V. M., Staels, B., and Yan, D. (2016) ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis. Circ Res 119, 1296-1312. (IF: 23.2，1區(qū)，編輯評(píng)述文章)

11、Zhong, W., Yi, Q., Xu, B., Li, S., Wang, T., Liu, F., Zhu, B., Hoffmann, P. R., Ji, G., Lei, P., Li, G., Li, J., Li, J., Olkkonen, V. M., and Yan, D. (2016) ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun 7, 12702. (IF: 17.6，1區(qū))

12、Zhong, W., Qin, S., Zhu, B., Pu, M., Liu, F., Wang, L., Ye, G., Yi, Q., and Yan, D. (2015) Oxysterol-binding protein-related protein 8 (ORP8) increases sensitivity of hepatocellular carcinoma cells to Fas-mediated apoptosis. J Biol Chem 290, 8876-8887. (IF: 5.4，2區(qū)TOP)