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閆道廣

來(lái)源： 發(fā)布時(shí)間：2025-03-18瀏覽：

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閆道廣，博士，教授，“南山學(xué)者”杰出人才，博士生導(dǎo)師，博士后合作導(dǎo)師

基本情況簡(jiǎn)介：

主要研究方向是磷脂與腫瘤發(fā)生。利用全基因組篩選、單細(xì)胞空間多組學(xué)分析、模式動(dòng)物等技術(shù)手段，開(kāi)展腫瘤（特別是病毒相關(guān)腫瘤）發(fā)生機(jī)制、腫瘤耐藥機(jī)制和相應(yīng)的臨床轉(zhuǎn)化等前沿研究。研究成果以通訊作者發(fā)表在Science Translational Medicine(2022)，Blood(2022)，Nature Communications(2022, 2016)，Circulation Research(2016)，Cell Reports(2019)，J Biol Chem(2018,2015)等期刊。主持科技部重大基礎(chǔ)研究（973）項(xiàng)目，國(guó)家自然科學(xué)基金重大研究計(jì)劃項(xiàng)目、面上項(xiàng)目等。

學(xué)術(shù)任職

1.中國(guó)生物化學(xué)和分子生物學(xué)學(xué)會(huì)脂質(zhì)和脂蛋白專業(yè)委員會(huì) 常務(wù)委員

2.中國(guó)病理生理學(xué)會(huì)動(dòng)脈粥樣硬化專業(yè)委員會(huì) 委員

3.國(guó)際動(dòng)脈粥樣硬化學(xué)會(huì)中國(guó)分會(huì) 理事

4.廣東省抗癌協(xié)會(huì)腫瘤代謝專業(yè)委員會(huì) 常務(wù)委員

聯(lián)系方式：Email: [email protected]；Tel: 15919309398。

研究領(lǐng)域

1.病毒相關(guān)腫瘤發(fā)生發(fā)展機(jī)理

2.磷脂代謝及信號(hào)轉(zhuǎn)導(dǎo)

3.小分子化合物和基因遞送靶向治療系統(tǒng)

科研項(xiàng)目

1.科技部重大基礎(chǔ)研究（973）項(xiàng)目(2012CB517502)

2.國(guó)家自然科學(xué)基金重大研究計(jì)劃項(xiàng)目培育項(xiàng)目（91439122）

3.國(guó)家自然科學(xué)基金面上項(xiàng)目（32071280，81770438，30971104）

4.廣東省自然科學(xué)基金重點(diǎn)項(xiàng)目（2017A030308002）

學(xué)術(shù)任職

1.中國(guó)生物化學(xué)和分子生物學(xué)學(xué)會(huì)脂質(zhì)和脂蛋白專業(yè)委員會(huì) 常務(wù)委員

2.中國(guó)病理生理學(xué)會(huì)動(dòng)脈粥樣硬化專業(yè)委員會(huì) 委員

3.國(guó)際動(dòng)脈粥樣硬化學(xué)會(huì)中國(guó)分會(huì) 理事

4.廣東省抗癌協(xié)會(huì)腫瘤代謝專業(yè)委員會(huì) 常務(wù)委員

代表性論著

1. Zhu B., Zhong W., Pan G., Cao X., Xu M., Zheng J., Chen H., Feng X., Luo C., Lu C., Lin W., Lai C., Du X., Yi Q., Yan D. (2022) Loss of miR-31-5p drives hematopoietic stem cell deterioration and restoration eliminates leukemia stem cells. Sci Transl Med 14(629):eabh2548. (IF: 19.3), 新華社報(bào)道 （http://www.news.cn/english/20220127/bfa3590bda504df9ad495cd1bcff974b/c.html）.

2. Zhong，W., Cao X., Pan G., Niu Q., Feng X., Xu M., Li M., Huang Y., Yi Q., Yan D. (2022) Oxysterol-binding protein-related protein 4L (ORP4L) is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1 (HTLV-1). Blood. 139 (7): 1052–1065. (IF: 25.4)

3. Zhong W, Lin W, Yang Y, Chen D, Cao X, Xu M, Pan G, Chen H, Zheng J, Feng X, Yang LH, Lai C, Olkkonen VM, Xu J, Cui S, Yan D. (2022) An acquired PI(4)P transport initiates T-cell deterioration. Nat Commun. 29;13(1):4390. (IF：17.6)。

4. Xu, M., Zhu, B., Cao, X., Li, S., Li, D., Zhou, H., Olkkonen, V. M., Zhong, W., Xu, J., and Yan, D. (2020) OSBP-Related Protein 5L Maintains Intracellular IP3/Ca(2+) Signaling and Proliferation in T Cells by Facilitating PIP2 Hydrolysis. J Immunol 204, 1134-1145. (IF: 5.4)

5. Cao, X., Chen, J., Li, D., Xie, P., Xu, M., Lin, W., Li, S., Pan, G., Tang, Y., Xu, J., Olkkonen, V. M., Yan, D., and Zhong, W. (2019) ORP4L couples IP3 to ITPR1 in control of endoplasmic reticulum calcium release. FASEB J 33, 13852-13865. (IF: 5.8)

6. Zhu, B., Cao, X., Zhang, W., Pan, G., Yi, Q., Zhong, W., and Yan, D. (2019) MicroRNA-31-5p enhances the Warburg effect via targeting FIH. FASEB J 33, 545-556. (IF: 5.8，ESI高被引論文)

7. Zhong, W., Xu, M., Li, C., Zhu, B., Cao, X., Li, D., Chen, H., Hu, C., Li, R., Luo, C., Pan, G., Zhang, W., Lai, C., Wang, T., Du, X., Chen, H., Xu, G., Olkkonen, V. M., Lei, P., Xu, J., and Yan, D. (2019) ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCbeta3 Catalysis: Targeting It Eradicates Leukemia Stem Cells. Cell Rep 26, 2166-2177 e2169. (IF: 9.9)，中國(guó)科學(xué)報(bào)報(bào)道（https://news.sciencenet.cn/sbhtmlnews/2019/2/343620.shtm）.

8. Pan, G., Cao, X., Liu, B., Li, C., Li, D., Zheng, J., Lai, C., Olkkonen, V. M., Zhong, W., and Yan, D. (2018) OSBP-related protein 4L promotes phospholipase Cbeta3 translocation from the nucleus to the plasma membrane in Jurkat T-cells. J Biol Chem 293, 17430-17441. (IF: 5.4)

9. Zhong, W., Pan, G., Wang, L., Li, S., Ou, J., Xu, M., Li, J., Zhu, B., Cao, X., Ma, H., Li, C., Xu, J., Olkkonen, V. M., Staels, B., and Yan, D. (2016) ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis. Circ Res 119, 1296-1312. (IF: 23.2，編輯評(píng)述文章)

10. Zhong, W., Yi, Q., Xu, B., Li, S., Wang, T., Liu, F., Zhu, B., Hoffmann, P. R., Ji, G., Lei, P., Li, G., Li, J., Li, J., Olkkonen, V. M., and Yan, D. (2016) ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun 7, 12702. (IF: 17.6)

11. Li, J., Zheng, X., Lou, N., Zhong, W., and Yan, D. Oxysterol binding protein-related Protein 8 (ORP8) mediates the cytotoxicity of 25-Hydroxycholesterol. J Lipid Res, 57: 1845-1853, (2016). (IF: 6.6)

12. Zhong, W., Qin, S., Zhu, B., Pu, M., Liu, F., Wang, L., Ye, G., Yi, Q., and Yan, D. (2015) Oxysterol-binding protein-related protein 8 (ORP8) increases sensitivity of hepatocellular carcinoma cells to Fas-mediated apoptosis. J Biol Chem 290, 8876-8887. (IF: 5.4)

13. Zhong, W., Zhou, Y., Li, J., Mysore, R., Luo, W., Li, S., Chang, M. S., Olkkonen, V. M., and Yan, D. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. Exp Cell Res 322, 227-235, (2014). (IF: 4.1)

14. Ma, H., Zhong, W., Jiang, Y., Fontaine, C., Li, S., Fu, J., Olkkonen, V. M., Staels, B., and Yan, D. Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbalpha knock- down. J Am Heart Assoc 2, e000235, (2013). (IF: 6.1)

15. Zhong, W., Zhou, Y., Li, S., Zhou, T., Ma, H., Wei, K., Li, H., Olkkonen, V. M., and Yan, D. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Exp Cell Res 317, 2353-2363, (2011). (IF: 4.1)

16. Yan D, M?yr?np?? MI, Wong J, Perttil? J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM. OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J Biol Chem 4;283(1):332-340,(2008). (IF: 5.4)

17. Yan D, Jauhiainen M, Hildebrand RB, Willems van Dijk K, Van Berkel TJ, Ehnholm C, Van Eck M, Olkkonen VM. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 27(7):1618-24,(2007). (IF:10.5)

18. Yan D, Lehto M, Rasilainen L, Metso J, Ehnholm C, Yl?-Herttuala S, Jauhiainen M, Olkkonen VM. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Arterioscler Thromb Vasc Biol. 27(5):1108-14,(2007). (IF:10.5)