李楠，廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院內(nèi)三科，副主任醫(yī)師，碩士生導(dǎo)師

基本情況簡(jiǎn)介：

畢業(yè)于中南大學(xué)，獲博士學(xué)位。在廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院內(nèi)三科工作13年，擔(dān)任廣東省抗癌協(xié)會(huì)靶向治療專委會(huì)常務(wù)委員，廣東省抗癌協(xié)會(huì)大腸癌專委會(huì)委員，廣東省中西結(jié)合學(xué)會(huì)生物治療專委會(huì)青年委員，廣州市醫(yī)學(xué)會(huì)腫瘤學(xué)分會(huì)委員兼秘書(shū)，廣州市抗癌協(xié)會(huì)青年委員會(huì)委員。主持國(guó)家和省部級(jí)課題5項(xiàng)（在研2型，研究經(jīng)費(fèi)50萬(wàn)元），近5年第一作者或通訊作者發(fā)表SCI收錄論文4篇，獲得專利授權(quán)1項(xiàng)。

聯(lián)系方式:郵箱[email protected]；

研究領(lǐng)域

1、腫瘤微環(huán)境與腫瘤免疫

科研項(xiàng)目

1. 廣東省自然科學(xué)基金, 青年提升項(xiàng)目, 2023A151503005, LPCAT2抑制結(jié)直腸癌發(fā)生發(fā)展的腫瘤本身和腫瘤微環(huán)境機(jī)制研究, 2023-01 至 2025-12, 30萬(wàn)元, 在研, 主持

2. 廣東省自然科學(xué)基金, 面上項(xiàng)目, 2021A1515010988, S100A8/FOXP1信號(hào)介導(dǎo)腫瘤細(xì)胞與巨噬細(xì)胞交互促進(jìn)結(jié)直腸癌進(jìn)展, 2021-01 至 2023-12, 10萬(wàn)元, 結(jié)題, 主持

3. 市校聯(lián)合項(xiàng)目，LPCAT2在腫瘤細(xì)胞和巨噬細(xì)胞交互調(diào)控結(jié)直腸癌發(fā)生發(fā)展中的作用機(jī)制及生物學(xué)意義，2023-04至2025-04，20萬(wàn)元，在研，主持

代表性論著（*第一作者，#通訊作者）

1. Cao Nan, Zhang Fangmei, Yin Jiang, Zhang Jianlei, Bian Xiqing, Zheng Guopei, Li Nan^#, Lin Ying, Luo Liyun. LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11axis, ONCOGENE, 2024, 43(22): 1714-1725

2. Nan Li^*, Guohua Yang, Liyun Luo, Li Ling, Xiaorong Wang, lejuan Shi, Junsong Lan, Xiaoting Jia, Qiong Zhang, Ze Long, Jinbao Liu, Weimin Hu, Zhimin He, Haiying Liu, Wangqing Liu, GuopeiZheng. LncRNA THAP9-AS1 Promotes Pancreatic Ductal Adenocarcinoma Growth and Leads to a Poor Clinical Outcome via Sponging miR-484 and Interacting with YAP, Clinical Cancer Research, 2020,26(7): 1736-1748.

3. Nan Li^*, Nanrong Yu, Jia Wang, Haofeng Xi, Weiqun Lu, Houwei Xu, Min Deng, Guopei Zheng, Haiying Liu. MiR-222/VGLL4/YAP-TEAD1 regulatory loop promotes proliferation and invasion of gastric cancer cells, American Journal of Cancer Research, 2015, 5(3): 1158-1168.

4. Nan Li^*, Anliu Tang, Shuo Huang, Zeng Li, Xiayu Li, Shourong Shen, Jian Ma, Xiaoyan Wang. MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway, Molecular and Cellular Biochemistry, 2013, 380(1-2): 107-119.

5. Anliu Tang, Nan Li^*, Xiayu Li, Hongyuan Yang, Wei Wang, Liyang Zhang, Guiyuan Li, Wei Xiong, Jian Ma, Shourong Shen. Dynamic activation of the key pathway:linking colitis tocolorectal cancer in mouse model, Carcinogenesis, 2012, 33(7): 1375-1383.

6. Li Zhihui, Zhang Jialei, Yin Jiang, Ma wen, Liao Hongfan, Ling Lv, Zou Qingfeng, Song Ying, Zheng Guopei, Hu Xiaoye, Yang Guohua, Li Nan^#. Targeting MYOF Suppresses Pancreatic Ductal Adenocarcinoma Progression by Inhibiting ILF3-LCN2 SignalingThrough Disrupting OTUB1-Mediated Deubiquitination of ILF3. Redox Biology（修稿中）

7. Jianlei Zhang, Zhihui Li, Wen Ma, Weina Fan, Jing Dong, Jingjie Tian, Hongfan Liao, Yabing Cao, Qiong Zhang, Jiang Yin, Guopei Zheng, Nan Li^#. LAMA4+ cancer-associated fibroblasts provide immunosuppressive microenvironment for liver cancer via induction of T-cell senescence. Cell Communication and Signaling （已于2025-02-25（第二次小修，修回）