羅凱，廣州醫(yī)科大學附屬腫瘤醫(yī)院檢驗科，主任技師，碩士生導(dǎo)師
基本情況簡介：
在廣州醫(yī)科大學附屬腫瘤醫(yī)院檢驗科工作十五年，擔任檢驗科副主任、廣東省基層醫(yī)藥學會檢驗專業(yè)委員會副主任委員、廣東省精準醫(yī)學應(yīng)用學會臨床生物信息分會常務(wù)委員、廣東省精準醫(yī)學應(yīng)用學會罕見腫瘤分會常務(wù)委員、廣東省衛(wèi)生經(jīng)濟學會檢驗經(jīng)濟分會常務(wù)委員、
廣東省醫(yī)學會精準醫(yī)學與分子診斷學分委會委員、廣州市醫(yī)師協(xié)會檢驗醫(yī)師分會副主任委員、廣州市醫(yī)學會微生物學與免疫學分會副主任委員、廣州市醫(yī)院協(xié)會檢驗專業(yè)委員會副主任委員、廣州市醫(yī)學會檢驗醫(yī)學分會常務(wù)委員、廣州市醫(yī)學會檢驗醫(yī)學分會新技術(shù)學組組長、廣州市醫(yī)學會精準分子診斷學分會常務(wù)委員。
主持國家和省部級課題1項，發(fā)表論文二十余篇，獲得專利授權(quán)4項。
聯(lián)系方式:電話020-66673666；郵箱[email protected]；
研究領(lǐng)域
腫瘤生物標志物篩選、檢測與靶向治療耐藥機制研究
科研項目
1、廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究項目，Circ-WHSC1調(diào)控非小細胞肺癌奧希替尼耐藥的機制及其作為耐藥標志物的臨床價值，2023年-2026年，10萬
代表性論著（*第一作者，#通訊作者）
(1) Xiaoting Jia *, Jingjie Tian * , Pingping Chen * , Jing Dong , Lei Li , Danyang Chen , JianleiZhang , DongjiangLiao# , ZhiminHe# , KaiLuo#.Methylation-modulated PFTK1 regulates gefitinib resistance via Wnt/β-catenin signaling in EGFR mutant non-small-cell lung cancer cells, Commun Biol, 2024, 7(1):1649.
(2)Siwen Fan *, Xinwu Lv * , Chuantao Zhang * , Bingbing Zeng , Yanqing Liang , Danyang Chen , Zumin Xu , Pan Li , Shanshan Wu , Hao Liu , Kai Luo# , Zongcai Liu #, Yanmei Yi#. METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells, Mol Cancer Res, 2024,22(11):1051-1063.
(3) Ting Zhu* , Junjun Wang* , Juan Li* , Qichao Zhang , YanyanShang, Junhao Zhou , Ling Min , Bo Lv# , Kai Luo# . A serum LncRNA signature for predicting prognosis of triple-negative breast cancer, Clin Chim Acta, 2023,549:117535.
(4) Hao Liu* , Xiaoting Jia* , Kai Luo* , Xiangzhou Chen , Zhijie Zhang , Danyang Chen, Yixue Gu, Zhimin He#, Guopei Zheng#. TCRP1 activated by mutant p53 promotes NSCLC proliferation via inhibiting FOXO3a, Oncogenesis,2022,11(1):19.
(5) Jun Wang* , Xi Liu* , Yuanfeng Huang*, Pan Li , Minqiang Yang , Shanshan Zeng , DanyangChen , QianWang, HaoLiu# , Kai Luo# , Jin Deng#. Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells, Cell Death Discov, 2022, 8(1): 170.
(6) Yanmei Yi*, Pan Li*, Yuanfeng Huang*, Danyang Chen, Siwen Fan, Jun Wang,Minqiang Yang, Shanshan Zeng, Jin Deng, Xinwu Lv, Kai Luo#, Zhiwei He#, Hao Liu#. P21-activated kinase 2-mediated β-catenin 1 signaling promotes cancer stemness and osimertinib resistance inEGFR-mutant non-small-cell lung cancer, Oncogene, 2022, 41(37):4318-4329.https://doi.org/10.1038/s41388-022-02438-z.
(7) Ting Liu*, Wei Guo*, Kai Luo*, Lei Li, Jing Dong , Meijun Liu, Xingyuan Shi, Zhiyuan Wang , Jianlei Zhang , Jiang Yin, Ni Qiu , Minying Lu , Danyang Chen, Xiaoting Jia, Hao Liu , Yixue Gu , Yan Xiong , Guopei Zheng , Gang Xu# , Zhimin He# , Zhijie Zhang#. Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer, Int J Biol Sci, 2022, 18(11): 4497-4512.
(8) Jianlei Zhang*, Liyun Luo*, Jing Dong, Meijun Liu, Dongfeng Zhai, Danqing Huang, Li Ling, Xiaoting Jia, Kai Luo#, Guopei Zheng#.A prognostic 11-DNA methylation signature for lung squamous cell carcinoma [J]. Journal of Thoracic Disease,2020,12(5):2569-2582.
